Isolation and characterization of broad and ultrapotent human monoclonal antibodies with therapeutic activity against chikungunya virus

Chikungunya virus (CHIKV) is a mosquito-transmitted RNA virus that causes acute febrile infection associated with polyarthralgia in humans. Mechanisms of protective immunity against CHIKV are poorly understood, and no effective therapeutics or vaccines are available. We isolated and characterized hu...

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Библиографические подробности
Опубликовано в: :Cell Host Microbe
Главные авторы: Smith, Scott A., Silva, Laurie A., Fox, Julie M., Flyak, Andrew, Kose, Nurgun, Sapparapu, Gopal, Khomadiak, Solomiia, Ashbrook, Alison W., Kahle, Kristen M., Fong, Rachel H., Swayne, Sherri, Doranz, Benjamin J., McGee, Charles E., Heise, Mark T., Pal, Pankaj, Brien, James D., Austin, S. Kyle, Diamond, Michael S., Dermody, Terence S., Crowe, James E.
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501771/
https://ncbi.nlm.nih.gov/pubmed/26159721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2015.06.009
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