Development of a Novel Virus-Like Particle Vaccine Platform That Mimics the Immature Form of Alphavirus

Virus-like particles (VLPs) are noninfectious multiprotein structures that are engineered to self-assemble from viral structural proteins. Here, we developed a novel VLP-based vaccine platform utilizing VLPs from the chikungunya virus. We identified two regions within the envelope protein, a structu...

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Dettagli Bibliografici
Pubblicato in:Clin Vaccine Immunol
Autori principali: Urakami, Akane, Sakurai, Atsuko, Ishikawa, Momoko, Yap, Moh Lan, Flores-Garcia, Yevel, Haseda, Yasunari, Aoshi, Taiki, Zavala, Fidel P., Rossmann, Michael G., Kuno, Sachiko, Ueno, Ryuji, Akahata, Wataru
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2017
Soggetti:
Vaccines
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5498722/
https://ncbi.nlm.nih.gov/pubmed/28515133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00090-17
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