Molecular mechanisms of synaptic vesicle priming by Munc13 and Munc18

Munc13 catalyzes the transit of syntaxin from a closed complex with Munc18 into the ternary SNARE complex. Here we report a new function of Munc13, independent of Munc18: it promotes the proper syntaxin / synaptobrevin subconfiguration during assembly of the ternary SNARE complex. In cooperation wit...

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Pubblicato in:Neuron
Autori principali: Lai, Ying, Choi, Ucheor B., Leitz, Jeremy, Rhee, Hong Jun, Lee, Choongku, Altas, Bekir, Zhao, Minglei, Pfuetzner, Richard A., Wang, Austin L., Brose, Nils, Rhee, JeongSeop, Brunger, Axel T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5747255/
https://ncbi.nlm.nih.gov/pubmed/28772123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2017.07.004
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