Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4

The caspase activation and recruitment domain (CARD)-based inflammasome sensors NLRP1b and NLRC4 induce caspase-1-dependent pyroptosis independent of the inflammasome adaptor ASC. Here, we show that NLRP1b and NLRC4 trigger caspase-8-mediated apoptosis as an alternative cell death program in caspase...

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Publicado en:Cell Rep
Main Authors: Van Opdenbosch, Nina, Van Gorp, Hanne, Verdonckt, Maarten, Saavedra, Pedro H.V., de Vasconcelos, Nathalia M., Gonçalves, Amanda, Vande Walle, Lieselotte, Demon, Dieter, Matusiak, Magdalena, Van Hauwermeiren, Filip, D’Hont, Jinke, Hochepied, Tino, Krautwald, Stefan, Kanneganti, Thirumala-Devi, Lamkanfi, Mohamed
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5746600/
https://ncbi.nlm.nih.gov/pubmed/29262324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.11.088
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