Structure-activity relationship studies on a series of 3α-[bis(4-fluorophenyl)methoxy]tropanes and 3α-[bis(4-fluorophenyl)methylamino]tropanes as novel atypical dopamine transporter (DAT) inhibitors for the treatment of cocaine use disorders

The development of medications to treat cocaine use disorders has thus far defied success, leaving this patient population without pharmacotherapeutic options. As the dopamine transporter (DAT) plays a prominent role in the reinforcing effects of cocaine that can lead to addiction, atypical DAT inhi...

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Publicado en:J Med Chem
Autores principales: Zou, Mu-Fa, Cao, Jianjing, Abramyan, Ara M., Kopajtic, Theresa, Zanettini, Claudio, Guthrie, Daryl A., Rais, Rana, Slusher, Barbara S., Shi, Lei, Loland, Claus J., Newman, Amy Hauck
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5746459/
https://ncbi.nlm.nih.gov/pubmed/29227643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01454
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