Strong fascin expression promotes metastasis independent of its F-actin bundling activity

High expression of the actin bundling protein Fascin increases the malignancy of tumor cells. Here we show that fascin expression is up-regulated in more malignant sub-cell lines of MDA-MB-231 cells as compared to parental cells. Since also parental MDA-MB-231 cells exhibit high fascin levels, incre...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Heinz, Lisa S., Muhs, Stefanie, Schiewek, Johanna, Grüb, Saskia, Nalaskowski, Marcus, Lin, Yuan-Na, Wikman, Harriet, Oliveira-Ferrer, Leticia, Lange, Tobias, Wellbrock, Jasmin, Konietzny, Anja, Mikhaylova, Marina, Windhorst, Sabine
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5746366/
https://ncbi.nlm.nih.gov/pubmed/29299131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22249
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