Multiple mechanisms underlying neuroprotection by secretory phospholipase A2 preconditioning in a surgically induced brain injury rat model

BACKGROUND: Intra-operative bleeding, post-operative brain edema and neuroinflammation are major complications in patients with surgical brain injury (SBI). Phospholipase A2 (PLA2)is the upstream enzyme which initiates the PLA2, 5-lipoxygenase (5-LOX) and leukotriene B4 (LTB4) inflammatory pathway....

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Udgivet i:Exp Neurol
Main Authors: Wang, Yuechun, Sherchan, Prativa, Huang, Lei, Akyol, Onat, McBride, Devin W., Zhang, John H.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745263/
https://ncbi.nlm.nih.gov/pubmed/29074417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2017.10.022
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