Recombinant Slit2 Attenuates Neuroinflammation After Surgical Brain Injury by Inhibiting Peripheral Immune Cell Infiltration via Robo1-srGAP1 Pathway in a Rat Model

BACKGROUND AND PURPOSE: Peripheral immune cell infiltration to the brain tissue at the perisurgical site can promote neuroinflammation after surgical brain injury (SBI). Slit2, an extracellular matrix protein, has been reported to reduce leukocyte migration. This study evaluated the effect of recomb...

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Veröffentlicht in:Neurobiol Dis
Hauptverfasser: Sherchan, Prativa, Huang, Lei, Wang, Yuechun, Akyol, Onat, Tang, Jiping, Zhang, John H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4688150/
https://ncbi.nlm.nih.gov/pubmed/26550694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2015.11.003
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