Hypoxia promotes IL-32 expression in myeloma cells, and high expression is associated with poor survival and bone loss

Multiple myeloma (MM) is a hematologic cancer characterized by expansion of malignant plasma cells in the bone marrow. Most patients develop an osteolytic bone disease, largely caused by increased osteoclastogenesis. The myeloma bone marrow is hypoxic, and hypoxia may contribute to MM disease progre...

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Gepubliceerd in:Blood Adv
Hoofdauteurs: Zahoor, Muhammad, Westhrin, Marita, Aass, Kristin Roseth, Moen, Siv Helen, Misund, Kristine, Psonka-Antonczyk, Katarzyna Maria, Giliberto, Mariaserena, Buene, Glenn, Sundan, Anders, Waage, Anders, Sponaas, Anne-Marit, Standal, Therese
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2017
Onderwerpen:
Lymphoid Neoplasia
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745138/
https://ncbi.nlm.nih.gov/pubmed/29296919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017010801
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