Hypoxia promotes IL-32 expression in myeloma cells, and high expression is associated with poor survival and bone loss

Multiple myeloma (MM) is a hematologic cancer characterized by expansion of malignant plasma cells in the bone marrow. Most patients develop an osteolytic bone disease, largely caused by increased osteoclastogenesis. The myeloma bone marrow is hypoxic, and hypoxia may contribute to MM disease progre...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Zahoor, Muhammad, Westhrin, Marita, Aass, Kristin Roseth, Moen, Siv Helen, Misund, Kristine, Psonka-Antonczyk, Katarzyna Maria, Giliberto, Mariaserena, Buene, Glenn, Sundan, Anders, Waage, Anders, Sponaas, Anne-Marit, Standal, Therese
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745138/
https://ncbi.nlm.nih.gov/pubmed/29296919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017010801
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