Short telomere length in IPF lung associates with fibrotic lesions and predicts survival

Telomere maintenance dysfunction has been implicated in the pathogenesis of Idiopathic Pulmonary Fibrosis (IPF). However, the mechanism of how telomere length is related to fibrosis in the lungs is unknown. Surgical lung biopsies of IPF patients typically show a heterogeneous pattern of non-fibrotic...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Snetselaar, Reinier, van Batenburg, Aernoud A., van Oosterhout, Matthijs F. M., Kazemier, Karin M., Roothaan, Suzan M., Peeters, Ton, van der Vis, Joanne J., Goldschmeding, Roel, Grutters, Jan C., van Moorsel, Coline H. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5744955/
https://ncbi.nlm.nih.gov/pubmed/29281671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0189467
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