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Telomere shortening and DNA damage in culprit cells of different types of progressive fibrosing interstitial lung disease

Pulmonary fibrosis is strongly associated with telomere shortening and increased DNA damage. Key cells in the pathogenesis involve alveolar type 2 (AT2) cells, club cells and myofibroblasts; however, to what extent these cells are affected by telomere shortening and DNA damage is not yet known. We s...

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Veröffentlicht in:ERJ Open Res
Hauptverfasser: van Batenburg, Aernoud A., Kazemier, Karin M., van Oosterhout, Matthijs F.M., van der Vis, Joanne J., Grutters, Jan C., Goldschmeding, Roel, van Moorsel, Coline H.M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: European Respiratory Society 2021
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8165375/
https://ncbi.nlm.nih.gov/pubmed/34084786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1183/23120541.00691-2020
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