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A Supercluster of Neutralizing Epitopes at the Interface of Ricin’s Enzymatic (RTA) and Binding (RTB) Subunits

As part of an effort to engineer ricin antitoxins and immunotherapies, we previously produced and characterized a collection of phage-displayed, heavy chain-only antibodies (V(H)Hs) from alpacas that had been immunized with ricin antigens. In our initial screens, we identified nine V(H)Hs directed a...

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Detalhes bibliográficos
Publicado no:Toxins (Basel)
Main Authors: Poon, Amanda Y., Vance, David J., Rong, Yinghui, Ehrbar, Dylan, Mantis, Nicholas J.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5744098/
https://ncbi.nlm.nih.gov/pubmed/29168727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins9120378
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