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Brucein D, a Naturally Occurring Tetracyclic Triterpene Quassinoid, Induces Apoptosis in Pancreatic Cancer through ROS-Associated PI3K/Akt Signaling Pathway

Brucein D (BD), a major active quassinoid in Brucea javanica, has exhibited pronounced anticancer activities. However, the biologic mechanisms have not been fully explored. In this study, BD exhibited more potent cytotoxic effect on pancreatic cancer (PanCa) cell lines, while exerted weaker cytotoxi...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Front Pharmacol
Κύριοι συγγραφείς: Lai, Zheng-Quan, Ip, Siu-Po, Liao, Hui-Jun, Lu, Zheng, Xie, Jian-Hui, Su, Zi-Ren, Chen, Yun-Long, Xian, Yan-Fang, Leung, Po-Sing, Lin, Zhi-Xiu
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Frontiers Media S.A. 2017
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5744014/
https://ncbi.nlm.nih.gov/pubmed/29311937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00936
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