Brucein D, a Naturally Occurring Tetracyclic Triterpene Quassinoid, Induces Apoptosis in Pancreatic Cancer through ROS-Associated PI3K/Akt Signaling Pathway

Brucein D (BD), a major active quassinoid in Brucea javanica, has exhibited pronounced anticancer activities. However, the biologic mechanisms have not been fully explored. In this study, BD exhibited more potent cytotoxic effect on pancreatic cancer (PanCa) cell lines, while exerted weaker cytotoxi...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Lai, Zheng-Quan, Ip, Siu-Po, Liao, Hui-Jun, Lu, Zheng, Xie, Jian-Hui, Su, Zi-Ren, Chen, Yun-Long, Xian, Yan-Fang, Leung, Po-Sing, Lin, Zhi-Xiu
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5744014/
https://ncbi.nlm.nih.gov/pubmed/29311937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00936
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