Isorhynchophylline Protects PC12 Cells Against Beta-Amyloid-Induced Apoptosis via PI3K/Akt Signaling Pathway

The neurotoxicity of amyloid-β (Aβ) has been implicated as a critical cause of Alzheimer's disease. Isorhynchophylline (IRN), an oxindole alkaloid isolated from Uncaria rhynchophylla, exerts neuroprotective effect against Aβ (25–35)-induced neurotoxicity in vitro. However, the exact mechanism f...

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Bibliographic Details
Main Authors: Xian, Yan-Fang, Lin, Zhi-Xiu, Mao, Qing-Qiu, Chen, Jian-Nan, Su, Zi-Ren, Lai, Xiao-Ping, Ip, Paul Siu-Po
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836301/
https://ncbi.nlm.nih.gov/pubmed/24319473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/163057
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