Efficacy of Hepatitis B Virus Ribonuclease H Inhibitors, a New Class of Replication Antagonists, in FRG Human Liver Chimeric Mice

Chronic hepatitis B virus infection cannot be cured by current therapies, so new treatments are urgently needed. We recently identified novel inhibitors of the hepatitis B virus ribonuclease H that suppress viral replication in cell culture. Here, we employed immunodeficient FRG KO mice whose livers...

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Détails bibliographiques
Publié dans:Antiviral Res
Auteurs principaux: Long, Kelly R., Lomonosova, Elena, Li, Qilan, Ponzar, Nathan L., Villa, Juan A., Touchette, Erin, Rapp, Stephen, Liley, R. Matt, Murelli, Ryan P., Grigoryan, Alexandre, Buller, R. Mark, Wilson, Lisa, Bial, John, Sagartz, John E., Tavis, John E.
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5743599/
https://ncbi.nlm.nih.gov/pubmed/29129708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2017.11.008
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