Efficacy of Hepatitis B Virus Ribonuclease H Inhibitors, a New Class of Replication Antagonists, in FRG Human Liver Chimeric Mice

Chronic hepatitis B virus infection cannot be cured by current therapies, so new treatments are urgently needed. We recently identified novel inhibitors of the hepatitis B virus ribonuclease H that suppress viral replication in cell culture. Here, we employed immunodeficient FRG KO mice whose livers...

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Detalhes bibliográficos
Publicado no:Antiviral Res
Main Authors: Long, Kelly R., Lomonosova, Elena, Li, Qilan, Ponzar, Nathan L., Villa, Juan A., Touchette, Erin, Rapp, Stephen, Liley, R. Matt, Murelli, Ryan P., Grigoryan, Alexandre, Buller, R. Mark, Wilson, Lisa, Bial, John, Sagartz, John E., Tavis, John E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5743599/
https://ncbi.nlm.nih.gov/pubmed/29129708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2017.11.008
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