Expression of the human telomerase reverse transcriptase gene is modulated by quadruplex formation in its first exon due to DNA methylation

DNA secondary structures and methylation are two well-known mechanisms that regulate gene expression. The catalytic subunit of telomerase, human telomerase reverse transcriptase (hTERT), is overexpressed in ∼90% of human cancers to maintain telomere length for cell immortalization. Binding of CCCTC-...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Li, Pei-Tzu, Wang, Zi-Fu, Chu, I.-Te, Kuan, Yen-Min, Li, Ming-Hao, Huang, Mu-Ching, Chiang, Pei-Chi, Chang, Ta-Chau, Chen, Chin-Tin
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2017
Matèries:
Gene Regulation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5743063/
https://ncbi.nlm.nih.gov/pubmed/29084850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.808022
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