Direct evidence of mitochondrial G-quadruplex DNA by using fluorescent anti-cancer agents

G-quadruplex (G4) is a promising target for anti-cancer treatment. In this paper, we provide the first evidence supporting the presence of G4 in the mitochondrial DNA (mtDNA) of live cells. The molecular engineering of a fluorescent G4 ligand, 3,6-bis(1-methyl-4-vinylpyridinium) carbazole diiodide (...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Huang, Wei-Chun, Tseng, Ting-Yuan, Chen, Ying-Ting, Chang, Cheng-Chung, Wang, Zi-Fu, Wang, Chiung-Lin, Hsu, Tsu-Ning, Li, Pei-Tzu, Chen, Chin-Tin, Lin, Jing-Jer, Lou, Pei-Jen, Chang, Ta-Chau
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Chemical Biology and Nucleic Acid Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666356/
https://ncbi.nlm.nih.gov/pubmed/26487635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1061
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