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Inhibition of Cancer Cell Migration and Invasion through Suppressing the Wnt1-mediating Signal Pathway by G-quadruplex Structure Stabilizers

WNT1 encodes a multifunctional signaling glycoprotein that is highly expressed in several malignant tumors. Patients with Wnt1-positive cancer are usually related to advanced metastasis. Here, we found that a stretch of G-rich sequences located at the WNT1 promoter region is capable of forming G-qua...

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Detalhes bibliográficos
Main Authors: Wang, Jing-Ming, Huang, Fong-Chun, Kuo, Margaret Hsin-Jui, Wang, Zi-Fu, Tseng, Ting-Yuan, Chang, Lien-Cheng, Yen, Shao-Jung, Chang, Ta-Chau, Lin, Jing-Jer
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031517/
https://ncbi.nlm.nih.gov/pubmed/24713700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.548230
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