Comparison of Whole Body SOD1 Knockout with Muscle-Specific SOD1 Knockout Mice Reveals a Role for Nerve Redox Signaling in Regulation of Degenerative Pathways in Skeletal Muscle

Aims: Lack of Cu,Zn-superoxide dismutase (CuZnSOD) in homozygous knockout mice (Sod1(−/−)) leads to accelerated age-related muscle loss and weakness, but specific deletion of CuZnSOD in skeletal muscle (mSod1KO mice) or neurons (nSod1KO mice) resulted in only mild muscle functional deficits and fail...

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Detalhes bibliográficos
Publicado no:Antioxid Redox Signal
Main Authors: Sakellariou, Giorgos K., McDonagh, Brian, Porter, Helen, Giakoumaki, Ifigeneia I., Earl, Kate E., Nye, Gareth A., Vasilaki, Aphrodite, Brooks, Susan V., Richardson, Arlan, Van Remmen, Holly, McArdle, Anne, Jackson, Malcolm J.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2018
Assuntos:
Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5743036/
https://ncbi.nlm.nih.gov/pubmed/29065712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2017.7249
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