Gene-edited human kidney organoids reveal mechanisms of disease in podocyte development

A critical event during kidney organogenesis is the differentiation of podocytes, specialized epithelial cells that filter blood plasma to form urine. Podocytes derived from human pluripotent stem cells (hPSC-podocytes) have recently been generated in nephron-like kidney organoids, but the developme...

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Publicado en:Stem Cells
Main Authors: Kim, Yong Kyun, Refaeli, Ido, Brooks, Craig R., Jing, Peifeng, Gulieva, Ramila E., Hughes, Michael R., Cruz, Nelly M., Liu, Yannan, Churchill, Angela J., Wang, Yuliang, Fu, Hongxia, Pippin, Jeffrey W., Lin, Lih Y., Shankland, Stuart J., Vogl, A. Wayne, McNagny, Kelly M., Freedman, Benjamin S.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5742857/
https://ncbi.nlm.nih.gov/pubmed/28905451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.2707
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