Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease

Polycystic kidney disease (PKD) is a life-threatening disorder, commonly caused by defects in polycystin-1 (PC1) or polycystin-2 (PC2), in which tubular epithelia form fluid-filled cysts (1, 2). A major barrier to understanding PKD is the absence of human cellular models that accurately and efficien...

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Detalhes bibliográficos
Publicado no:Nat Mater
Main Authors: Cruz, Nelly M., Song, Xuewen, Czerniecki, Stefan M., Gulieva, Ramila E., Churchill, Angela J., Kim, Yong Kyun, Winston, Kosuke, Tran, Linh M., Diaz, Marco A., Fu, Hongxia, Finn, Laura S., Pei, York, Himmelfarb, Jonathan, Freedman, Benjamin S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5936694/
https://ncbi.nlm.nih.gov/pubmed/28967916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmat4994
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