PRIMA-1 and PRIMA-1(Met) (APR-246): From Mutant/Wild Type p53 Reactivation to Unexpected Mechanisms Underlying Their Potent Anti-Tumor Effect in Combinatorial Therapies

p53 protects cells from genetic assaults by triggering cell-cycle arrest and apoptosis. Inactivation of p53 pathway is found in the vast majority of human cancers often due to somatic missense mutations in TP53 or to an excessive degradation of the protein. Accordingly, reactivation of p53 appears a...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Perdrix, Anne, Najem, Ahmad, Saussez, Sven, Awada, Ahmad, Journe, Fabrice, Ghanem, Ghanem, Krayem, Mohammad
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5742820/
https://ncbi.nlm.nih.gov/pubmed/29258181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers9120172
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