Variability in functional p53 reactivation by PRIMA-1(Met)/APR-246 in Ewing sarcoma

BACKGROUND: Though p53 mutations are rare in ES, there is a strong indication that p53 mutant tumours form a particularly bad prognostic group. As such, novel treatment strategies are warranted that would specifically target and eradicate tumour cells containing mutant p53 in this subset of ES patie...

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Detalles Bibliográficos
Main Authors: Aryee, D N T, Niedan, S, Ban, J, Schwentner, R, Muehlbacher, K, Kauer, M, Kofler, R, Kovar, H
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2013
Assuntos:
Molecular Diagnostics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3833220/
https://ncbi.nlm.nih.gov/pubmed/24129240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.635
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