Antitumor Effects of PRIMA-1 and PRIMA-1(Met) (APR246) in Hematological Malignancies: Still a Mutant P53-Dependent Affair?

Because of its role in the regulation of the cell cycle, DNA damage response, apoptosis, DNA repair, cell migration, autophagy, and cell metabolism, the TP53 tumor suppressor gene is a key player for cellular homeostasis. TP53 gene is mutated in more than 50% of human cancers, although its overall d...

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Dettagli Bibliografici
Pubblicato in:Cells
Autori principali: Menichini, Paola, Monti, Paola, Speciale, Andrea, Cutrona, Giovanna, Matis, Serena, Fais, Franco, Taiana, Elisa, Neri, Antonino, Bomben, Riccardo, Gentile, Massimo, Gattei, Valter, Ferrarini, Manlio, Morabito, Fortunato, Fronza, Gilberto
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
Soggetti:
Review
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7827888/
https://ncbi.nlm.nih.gov/pubmed/33430525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10010098
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