Antitumor Effects of PRIMA-1 and PRIMA-1(Met) (APR246) in Hematological Malignancies: Still a Mutant P53-Dependent Affair?

Because of its role in the regulation of the cell cycle, DNA damage response, apoptosis, DNA repair, cell migration, autophagy, and cell metabolism, the TP53 tumor suppressor gene is a key player for cellular homeostasis. TP53 gene is mutated in more than 50% of human cancers, although its overall d...

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Detalhes bibliográficos
Publicado no:Cells
Main Authors: Menichini, Paola, Monti, Paola, Speciale, Andrea, Cutrona, Giovanna, Matis, Serena, Fais, Franco, Taiana, Elisa, Neri, Antonino, Bomben, Riccardo, Gentile, Massimo, Gattei, Valter, Ferrarini, Manlio, Morabito, Fortunato, Fronza, Gilberto
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7827888/
https://ncbi.nlm.nih.gov/pubmed/33430525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10010098
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