Macrophage migration inhibitory factor mediates protease‐activated receptor 4‐induced bladder pain through urothelial high mobility group box 1

Macrophage migration inhibitory factor (MIF) mediates pain although the mechanisms are not well understood. Urothelial activation of protease activated receptor 4 (PAR4) results in urothelial MIF release, urothelial high mobility group box 1 (HMGB1) release and bladder pain in mice without bladder i...

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Detalhes bibliográficos
Publicado no:Physiol Rep
Main Authors: Ma, Fei, Kouzoukas, Dimitrios E., Meyer‐Siegler, Katherine L., Hunt, David E., Leng, Lin, Bucala, Richard, Vera, Pedro L.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5742707/
https://ncbi.nlm.nih.gov/pubmed/29263120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13549
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