Protease-Activated Receptor 4 Induces Bladder Pain through High Mobility Group Box-1

Pain is the significant presenting symptom in Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS). Activation of urothelial protease activated receptor 4 (PAR4) causes pain through release of urothelial macrophage migration inhibitory factor (MIF). High Mobility Group Box-1 (HMGB1), a chromatin-...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Kouzoukas, Dimitrios E., Ma, Fei, Meyer-Siegler, Katherine L., Westlund, Karin N., Hunt, David E., Vera, Pedro L.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4806866/
https://ncbi.nlm.nih.gov/pubmed/27010488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152055
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