Gene Expression Profiling of Multiple Sclerosis Pathology Identifies Early Patterns of Demyelination Surrounding Chronic Active Lesions

In multiple sclerosis (MS), activated microglia and infiltrating macrophages phagocytose myelin focally in (chronic) active lesions. These demyelinating sites expand in time, but at some point turn inactive into a sclerotic scar. To identify molecular mechanisms underlying lesion activity and halt,...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Hendrickx, Debbie A. E., van Scheppingen, Jackelien, van der Poel, Marlijn, Bossers, Koen, Schuurman, Karianne G., van Eden, Corbert G., Hol, Elly M., Hamann, Jörg, Huitinga, Inge
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5742619/
https://ncbi.nlm.nih.gov/pubmed/29312322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01810
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