Gene Expression Profiling of Multiple Sclerosis Pathology Identifies Early Patterns of Demyelination Surrounding Chronic Active Lesions

In multiple sclerosis (MS), activated microglia and infiltrating macrophages phagocytose myelin focally in (chronic) active lesions. These demyelinating sites expand in time, but at some point turn inactive into a sclerotic scar. To identify molecular mechanisms underlying lesion activity and halt,...

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Dettagli Bibliografici
Pubblicato in:Front Immunol
Autori principali: Hendrickx, Debbie A. E., van Scheppingen, Jackelien, van der Poel, Marlijn, Bossers, Koen, Schuurman, Karianne G., van Eden, Corbert G., Hol, Elly M., Hamann, Jörg, Huitinga, Inge
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2017
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5742619/
https://ncbi.nlm.nih.gov/pubmed/29312322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01810
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