Gene Expression Profiling of Multiple Sclerosis Pathology Identifies Early Patterns of Demyelination Surrounding Chronic Active Lesions

In multiple sclerosis (MS), activated microglia and infiltrating macrophages phagocytose myelin focally in (chronic) active lesions. These demyelinating sites expand in time, but at some point turn inactive into a sclerotic scar. To identify molecular mechanisms underlying lesion activity and halt,...

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Publicat a:Front Immunol
Autors principals: Hendrickx, Debbie A. E., van Scheppingen, Jackelien, van der Poel, Marlijn, Bossers, Koen, Schuurman, Karianne G., van Eden, Corbert G., Hol, Elly M., Hamann, Jörg, Huitinga, Inge
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2017
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5742619/
https://ncbi.nlm.nih.gov/pubmed/29312322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01810
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