Transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes

Here we report the transcriptional profile of human microglia, isolated from normal-appearing grey matter (GM) and white matter (WM) of multiple sclerosis (MS) and non-neurological control donors, to find possible early changes related to MS pathology. Microglia show a clear region-specific profile,...

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Dades bibliogràfiques
Publicat a:Nat Commun
Autors principals: van der Poel, Marlijn, Ulas, Thomas, Mizee, Mark R., Hsiao, Cheng-Chih, Miedema, Suzanne S. M., Adelia, Schuurman, Karianne G., Helder, Boy, Tas, Sander W., Schultze, Joachim L., Hamann, Jörg, Huitinga, Inge
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6416318/
https://ncbi.nlm.nih.gov/pubmed/30867424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08976-7
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