LC–MS/MS method for the quantification of masitinib in RLMs matrix and rat urine: application to metabolic stability and excretion rate

Masitinib (MST) is a selective tyrosine kinase inhibitor. Validated liquid chromatography tandem mass spectrometric method (LC–MS/MS) was developed for the quantification of MST in rat liver microsomes (RLMs) matrix. The developed method was applied to metabolic stability and excretion rate studies....

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Veröffentlicht in:Chem Cent J
Hauptverfasser: Amer, Sawsan M., Kadi, Adnan A., Darwish, Hany W., Attwa, Mohamed W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741569/
https://ncbi.nlm.nih.gov/pubmed/29274040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13065-017-0365-2
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