Opposing functions of heparanase-1 and heparanase-2 in cancer progression

Heparanase, the sole heparan sulfate degrading endoglycosidase, regulates multiple biological activities that enhance tumor growth, metastasis, angiogenesis and inflammation. Heparanase accomplishes this by degrading heparan sulfate and thereby regulating the bioavailability of heparin-binding prote...

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Bibliographic Details
Published in:Trends Biochem Sci
Main Authors: Vlodavsky, Israel, Gross-Cohen, Miriam, Weissmann, Marina, Ilan, Neta, Sanderson, Ralph D.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741533/
https://ncbi.nlm.nih.gov/pubmed/29162390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2017.10.007
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