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Proteoglycans in health and disease: New concepts for heparanase function in tumor progression and metastasis

Heparanase is an endo-β-D-glucuronidase capable of cleaving heparan sulfate (HS) side chains at a limited number of sites, yielding HS fragments of still appreciable size. Importantly, heparanase activity correlates with the metastatic potential of tumor-derived cells, attributed to enhance cell dis...

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Detalhes bibliográficos
Main Authors: Barash, Uri, Cohen-Kapaln, Victoria, Dowek, Ilana, Sanderson, Ralph D., Ilan, Neta, Vlodavsky, Israel
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000436/
https://ncbi.nlm.nih.gov/pubmed/20840586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2010.07799.x
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