Blunting of estrogen modulation of cardiac cellular chymase/RAS activity and function in SHR

The relatively low efficacy of ACE-inhibitors in the treatment of heart failure in women after estrogen loss may be due to their inability to reach the intracellular sites at which angiotensin (Ang) II is generated and/or the existence of cell-specific mechanisms in which ACE is not the essential pr...

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Bibliographic Details
Published in:J Cell Physiol
Main Authors: Ahmad, Sarfaraz, Sun, Xuming, Lin, Marina, Varagic, Jasmina, Zapata-Sudo, Gisele, Ferrario, Carlos M., Groban, Leanne, Wang, Hao
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741475/
https://ncbi.nlm.nih.gov/pubmed/28888034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.26179
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