Blunting of cardioprotective actions of estrogen in female rodent heart linked to altered expression of cardiac tissue chymase and ACE2

BACKGROUND: Diastolic dysfunction develops in response to hypertension and estrogen (E2) loss and is a forerunner to heart failure (HF) in women. The cardiac renin–angiotensin system (RAS) contributes to diastolic dysfunction, but its role with respect to E2 and blood pressure remain unclear. METHOD...

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Detalhes bibliográficos
Publicado no:J Renin Angiotensin Aldosterone Syst
Main Authors: da Silva, Jaqueline S., Gabriel-Costa, Daniele, Wang, Hao, Ahmad, Sarfaraz, Sun, Xuming, Varagic, Jasmina, Sudo, Roberto T, Ferrario, Carlos M, Dell Italia, Louis J, Zapata-Sudo, Gisele, Groban, Leanne
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805468/
https://ncbi.nlm.nih.gov/pubmed/28748720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1470320317722270
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