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Homeostatic control of Hpo/MST kinase activity through autophosphorylation-dependent recruitment of the STRIPAK PP2A phosphatase complex

The Hippo pathway controls organ size and tissue homeostasis through a kinase cascade leading from the Ste20-like kinase Hpo (MST1/2 in mammals) to the transcriptional coactivator Yki (YAP/TAZ in mammals). While previous studies have uncovered positive and negative regulators of Hpo/MST, how they ar...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Rep
Prif Awduron: Zheng, Yonggang, Liu, Bo, Wang, Li, Lei, Huiyan, Prieto, Katiuska Daniela Pulgar, Pan, Duojia
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741103/
https://ncbi.nlm.nih.gov/pubmed/29262338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.11.076
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