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SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK
The Hippo pathway controls tissue growth and homeostasis through a central MST-LATS kinase cascade. The scaffold protein SAV1 promotes the activation of this kinase cascade, but the molecular mechanisms remain unknown. Here, we discover SAV1-mediated inhibition of the PP2A complex STRIPAK(SLMAP) as...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5663475/ https://ncbi.nlm.nih.gov/pubmed/29063833 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.30278 |
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