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Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5
The tumor-suppressive Hippo pathway controls tissue homeostasis through balancing cell proliferation and apoptosis. Activation of the kinases Mst1/2 is a key upstream event in this pathway and remains poorly understood. Mst1/2 and their critical regulators RASSFs contain SARAH domains that can homo-...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3797246/ https://ncbi.nlm.nih.gov/pubmed/23972470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.07.008 |
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