Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5

The tumor-suppressive Hippo pathway controls tissue homeostasis through balancing cell proliferation and apoptosis. Activation of the kinases Mst1/2 is a key upstream event in this pathway and remains poorly understood. Mst1/2 and their critical regulators RASSFs contain SARAH domains that can homo-...

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Bibliographic Details
Main Authors: Ni, Lisheng, Li, Sheng, Yu, Jianzhong, Min, Jungki, Brautigam, Chad A., Tomchick, Diana R., Pan, Duojia, Luo, Xuelian
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3797246/
https://ncbi.nlm.nih.gov/pubmed/23972470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.07.008
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