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Homeostatic control of Hpo/MST kinase activity through autophosphorylation-dependent recruitment of the STRIPAK PP2A phosphatase complex
The Hippo pathway controls organ size and tissue homeostasis through a kinase cascade leading from the Ste20-like kinase Hpo (MST1/2 in mammals) to the transcriptional coactivator Yki (YAP/TAZ in mammals). While previous studies have uncovered positive and negative regulators of Hpo/MST, how they ar...
Enregistré dans:
| Publié dans: | Cell Rep |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5741103/ https://ncbi.nlm.nih.gov/pubmed/29262338 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.11.076 |
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