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Peptidoglycan Cross-Linking Activity of l,d-Transpeptidases from Clostridium difficile and Inactivation of These Enzymes by β-Lactams

In most bacteria, the essential targets of β-lactam antibiotics are the d,d-transpeptidases that catalyze the last step of peptidoglycan polymerization by forming 4→3 cross-links. The peptidoglycan of Clostridium difficile is unusual since it mainly contains 3→3 cross-links generated by l,d-transpep...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Sütterlin, Laetitia, Edoo, Zainab, Hugonnet, Jean-Emmanuel, Mainardi, Jean-Luc, Arthur, Michel
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740366/
https://ncbi.nlm.nih.gov/pubmed/29061738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01607-17
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