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Chitinase Induction Prior to Caspofungin Treatment of Experimental Invasive Aspergillosis in Neutropenic Rats Does Not Enhance Survival

Host chitinases, chitotriosidase and acidic mammalian chitinase (AMCase), improved the antifungal activity of caspofungin (CAS) against Aspergillus fumigatus in vitro. These chitinases are not constitutively expressed in the lung. Here, we investigated whether chitosan derivatives were able to induc...

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Podrobná bibliografie
Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Refos, Jeannine M., Vonk, Alieke G., ten Kate, Marian T., Verbrugh, Henri A., Bakker-Woudenberg, Irma A. J. M., van de Sande, Wendy W. J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740338/
https://ncbi.nlm.nih.gov/pubmed/29084744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00960-17
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