Addition of 17-(allylamino)-17-demethoxygeldanamycin to a suboptimal caspofungin treatment regimen in neutropenic rats with invasive pulmonary aspergillosis delays the time to death but does not enhance the overall therapeutic efficacy

Caspofungin (CAS) which is used as salvage therapy in patients with invasive pulmonary aspergillosis (IPA) inhibits the 1,3-β-D-glucan synthesis in Aspergillus fumigatus. Inhibiting 1,3-β-D-glucan synthesis induces a stress response and in an invertebrate model it was demonstrated that inhibiting th...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Refos, Jeannine M., Vonk, Alieke G., ten Kate, Marian T., Eadie, Kimberly, Verbrugh, Henri A., Bakker-Woudenberg, Irma A. J. M., van de Sande, Wendy W. J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5524388/
https://ncbi.nlm.nih.gov/pubmed/28742113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180961
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