Evidence Supporting a Role for Mammalian Chitinases in Efficacy of Caspofungin against Experimental Aspergillosis in Immunocompromised Rats

OBJECTIVES: Caspofungin, currently used as salvage therapy for invasive pulmonary aspergillosis (IPA), strangely only causes morphological changes in fungal growth in vitro but does not inhibit the growth. In vivo it has good efficacy. Therefore the question arises how this in vivo activity is reach...

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Main Authors: Verwer, Patricia E. B., ten Kate, Marian T., Falcone, Franco H., Morroll, Shaun, Verbrugh, Henri A., Bakker-Woudenberg, Irma A. J. M., van de Sande, Wendy W. J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3796522/
https://ncbi.nlm.nih.gov/pubmed/24155872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075848
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