Combination Therapy of Advanced Invasive Pulmonary Aspergillosis in Transiently Neutropenic Rats Using Human Pharmacokinetic Equivalent Doses of Voriconazole and Anidulafungin

At present, voriconazole (VOR) is the drug of first choice for treating invasive pulmonary aspergillosis (IPA). However, particularly in advanced stages of disease and in the severely immunocompromised host, the mortality remains substantial. The combination of VOR with an echinocandin may improve t...

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Detalhes bibliográficos
Main Authors: van de Sande, Wendy W. J., Mathot, Ron A. A., ten Kate, Marian T., van Vianen, Wim, Tavakol, Mehri, Rijnders, Bart J. A., Bakker-Woudenberg, Irma A. J. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681552/
https://ncbi.nlm.nih.gov/pubmed/19237647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01556-08
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