Combination Therapy of Advanced Invasive Pulmonary Aspergillosis in Transiently Neutropenic Rats Using Human Pharmacokinetic Equivalent Doses of Voriconazole and Anidulafungin

At present, voriconazole (VOR) is the drug of first choice for treating invasive pulmonary aspergillosis (IPA). However, particularly in advanced stages of disease and in the severely immunocompromised host, the mortality remains substantial. The combination of VOR with an echinocandin may improve t...

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Main Authors: van de Sande, Wendy W. J., Mathot, Ron A. A., ten Kate, Marian T., van Vianen, Wim, Tavakol, Mehri, Rijnders, Bart J. A., Bakker-Woudenberg, Irma A. J. M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681552/
https://ncbi.nlm.nih.gov/pubmed/19237647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01556-08
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