Cannabidiolic acid methyl ester, a stable synthetic analogue of cannabidiolic acid, can produce 5‐HT(1A) receptor‐mediated suppression of nausea and anxiety in rats

BACKGROUND AND PURPOSE: The aim of this study was to compare the abilities of cannabidiolic acid methyl ester (HU‐580) and cannabidiolic acid (CBDA) to enhance 5‐HT(1A) receptor activation in vitro and produce 5‐HT(1A)‐mediated reductions in nausea and anxiety in vivo. EXPERIMENTAL APPROACH: We inve...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Pertwee, Roger G, Rock, Erin M, Guenther, Kelsey, Limebeer, Cheryl L, Stevenson, Lesley A, Haj, Christeene, Smoum, Reem, Parker, Linda A, Mechoulam, Raphael
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740240/
https://ncbi.nlm.nih.gov/pubmed/29057454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14073
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