Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus

BACKGROUND AND PURPOSE: To evaluate the hypothesis that activation of somatodendritic 5-HT(1A) autoreceptors in the dorsal raphe nucleus (DRN) produces the anti-emetic/anti-nausea effects of cannabidiol (CBD), a primary non-psychoactive cannabinoid found in cannabis. EXPERIMENTAL APPROACH: The poten...

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Detalhes bibliográficos
Main Authors: Rock, EM, Bolognini, D, Limebeer, CL, Cascio, MG, Anavi-Goffer, S, Fletcher, PJ, Mechoulam, R, Pertwee, RG, Parker, LA
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Themed Section: Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423241/
https://ncbi.nlm.nih.gov/pubmed/21827451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01621.x
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