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Amelioration of autoimmunity with an inhibitor selectively targeting all active centres of the immunoproteasome
BACKGROUND AND PURPOSE: Multicatalytic endopeptidase complex‐like‐1 (β2i), low molecular mass polypeptide (LMP) 2 (β1i) and LMP7 (β5i) are the proteolytically active subunits of the immunoproteasome, a special type of proteasome mainly expressed in haematopoietic cells. Targeting LMP7 has been shown...
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5740239/ https://ncbi.nlm.nih.gov/pubmed/29034459 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14069 |
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